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Teen Science Cafe—Combating Cancer: Using Stem Cells to Explore Treatments for Leukemia
Tuesday, November 19, 2019 @ 6:30 PM-8:30 PMFree
Saint Louis Community College at BRDG Park
1005 North Warson Road, St. Louis, MO 63132 United States + Google Map
Important information on parking and exact cafe location sent with registration confirmation.
REGISTRATION REQUIRED. FREE and OPEN to Junior Academy of Science members and all middle and high school students in grades 6-12 from throughout the region. PRE-REGISTRATION for Junior Academy members ONLY thru Friday, November 15. General registration opens Saturday, November 16. Register below!
To join the Junior Academy of Science, or to find out more about the benefits of membership in the Junior Academy, click here.
6:30 pm – 7:00 pm: Dinner and Icebreaker
7:00 pm – 8:30 pm: Presentation & Activities
Featured Cafe Presenter: John F. DiPersio, M.D., Ph.D., Deputy Director, Alvin J. Siteman Cancer Center; Virginia E. and Samuel J. Golman Endowed Professor of Oncology; and Chief, Division of Oncology, Washington University School of Medicine in St. Louis
Leukemia is a disease that affects adults and children; it is the most common cancer in children and teens, accounting for almost 1 out of 3 cancers. Oncologist, Dr. John DiPersio’s research focuses on using blood stem cells for transplantation and genetic interventions to fight leukemia. This can include gene editing of T cells, one type of immune system cell. Learn how immunotherapy can make cancer treatment more effective. In this interactive Teen Cafe on fighting cancer, you’ll role play, research, argue, and defend your position in one of two medical ethics scenarios 1) around the use of HeLa cells, or 2) the use of aggressive clinical interventions in advanced cancer care treatment.
Cafe Presenter Bio:
My research focuses on fundamental and translational aspects of leukemia and stem cell biology. These studies include identification of genetic abnormalities in human leukemias, understanding processes involving stem cell and leukemia cell trafficking and clinical and translational programs in both leukemia/MDS and stem cell transplantation. My laboratory also utilizes unique mouse models of allogeneic stem cell transplantation to explore novel genetic and epigenetic interventions aimed at mitigating graft vs. host disease (GvHD) while maintaining graft vs. leukemia (GvL). I am also a PI of multiple clinical trials focused on the diagnosis and treatment of patients with hematologic malignancies or those undergoing allogeneic stem cell transplantation. As Deputy Director of the Siteman Cancer Center I oversee all clinical and basic science research in the cancer center, and I am active as a mentor of trainees and junior faculty and oversee faculty recruitment and retention in the Division. My personal research has focused on the role of stem cell transplantation and novel targeted interventions to alter the natural history of AML and other hematological malignancies. These studies have utilized bench-to-bedside mechanistic and preclinical modeling studies followed by early phase clinical trials. They have focused on targeting key elements of the hematopoietic niche for optimal stem cell mobilization and chemosensitization, mitigating GvHD in T replete transplants, understanding the genomic alterations in de novo and relapsed AML and developing and testing in the clinic novel therapeutics and immunotherapeutics for the treatment of AML before and after stem cell transplantation.
Teen Science Cafe an Academy of Science – St. Louis STEM Teens Experience.